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Check Intently (one)phenobarbital will lessen the level or influence of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of fentanyl with CYP3A4 inducers could lead into a decrease in fentanyl plasma concentrations, deficiency of efficacy or, possibly, developm